ABSTRACT

Year : 2022  |  Volume : 6  |  Issue : 2  |  Page : 91

Poster Presentation: AB No: 142: Biological markers as an outcome measure of exercise in Osteoarthritis Rehabilitation: A Scoping Review

Aravind B, Angeline R, Venkatesh N, Sweatha Nathan R
Faculty of Physiotherapy, Sri Ramachandra Institute of Higher Education and Research (Deemed To Be University)

Correspondence Address:

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2456-7787.361079

Background: Knee osteoarthritis characterized by degeneration, loss of articular cartilage, and osteophyte formation. The presentation includes pain, tenderness, stiffness, joint swelling, limited mobility, joint deformities, and intermittent periods of synovial membrane inflammation and release of biomarkers of inflammation. Change in cartilage volume and circulating biomarker levels may be influenced by therapeutic exercise. Exercise therapy has been proved to improve joint function, physical function and quality of life. Biomarkers helps to determine the benefits of exercise in knee osteoarthritis this information can be a measurable indicator to document the therapy benefits. This study aims to perform a scoping review of the rehabilitative biomarkers used to measure the therapy outcomes in knee osteoarthritis. Objectives: To analyse and identify the biomarkers used to measure the therapy outcomes in knee osteoarthritis by conducting a scoping review. Methodology: Literature search up to October 2021 in databases like MEDLINE via PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science. Data was extracted from the available literature. A narrative synthesis of the various markers and its efficacy in measuring the therapy benefits in knee osteoarthritis was performed. Results: Ten of the seventeen studies were randomized control trail, three cohort studies, two pilot study, two cross sectional studies and three pilot studies at 4-to-24-weeks following exercises were included. A total of 1897 sample were included. Out of 17 biomarkers 3 studies investigated cartilage synthesis, 16 studies investigated markers of cartilage degradation, 2 studies investigated synovial synthesis, 1 studied using markers of synovial degradation, 2 investigated using extracellular matrix, 8 investigated using inflammatory markers. All were found to be potential markers to measure the therapy benefit. Conclusion: The information provided from 17 studies, exercise was proven to be a safe, acceptable, and effective method of intervention for certain health outcomes and the biomarkers used were found to be potential markers to objectively document therapy outcomes.

Keywords: Exercise therapy outcomes, Biomarker, Knee Osteoarthrtis